Drug interactions
Cyclophosphamide + Enoxaparin
Severity: Moderate
Cyclophosphamide and Enoxaparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide can cause thrombocytopenia, which adds to the bleeding risk of therapeutic or prophylactic low molecular weight heparin. The interaction is mainly through chemotherapy-induced low platelet counts.
What this interaction means in plain words
Cyclophosphamide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Enoxaparin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia combined with anticoagulation.
What to do
Monitor platelet counts regularly and withhold or reduce enoxaparin dosing if platelets fall below locally accepted thresholds, and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Enoxaparin
- Defibrotide + Enoxaparin Contraindicated
- Enoxaparin + Ketorolac Contraindicated
- Enoxaparin + Mifepristone Contraindicated
- Abciximab + Enoxaparin Major
- Aceclofenac + Enoxaparin Major
- Acetylsalicylic acid + Enoxaparin Major
Frequently asked questions
Can I take Cyclophosphamide with Enoxaparin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Enoxaparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide can cause thrombocytopenia, which adds to the bleeding risk of therapeutic or prophylactic low molecular weight heparin. The interaction is mainly through chemotherapy-induced low platelet counts.
How serious is the interaction between Cyclophosphamide and Enoxaparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts regularly and withhold or reduce enoxaparin dosing if platelets fall below locally accepted thresholds, and watch for bleeding.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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