Drug interactions
Cyclophosphamide + Hydrochlorothiazide-telmisartan
Severity: Moderate
Cyclophosphamide and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may reduce renal clearance of cyclophosphamide and its metabolites and have been reported to deepen myelosuppression. The result can be more pronounced leukopenia and infection risk.
What this interaction means in plain words
Cyclophosphamide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Reduced renal clearance and possible increased exposure to cytotoxic metabolites; mechanism not fully established.
What to do
Monitor complete blood counts closely during chemotherapy. Consider holding or replacing the thiazide if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Cyclophosphamide and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may reduce renal clearance of cyclophosphamide and its metabolites and have been reported to deepen myelosuppression. The result can be more pronounced leukopenia and infection risk.
How serious is the interaction between Cyclophosphamide and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during chemotherapy. Consider holding or replacing the thiazide if marked myelosuppression occurs.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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