Drug interactions
Cyclophosphamide + Hydrochlorothiazide-valsartan
Severity: Moderate
Cyclophosphamide and Hydrochlorothiazide-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase the myelosuppressive effect of cyclophosphamide, leading to more pronounced leukopenia. The effect has been reported in limited data. Thiazide-induced fluid and electrolyte shifts may also be relevant.
What this interaction means in plain words
Cyclophosphamide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Hydrochlorothiazide-valsartan belongs to Cardiovascular.
Why it happens
Thiazides may reduce renal clearance of cyclophosphamide or its metabolites; the mechanism is not fully established.
What to do
Monitor complete blood counts closely during cyclophosphamide therapy. Adjust the cyclophosphamide dose according to neutrophil counts, and consider an alternative antihypertensive if cytopenias are severe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-valsartan
- Aliskiren + Hydrochlorothiazide-valsartan Contraindicated
- Dofetilide + Hydrochlorothiazide-valsartan Contraindicated
- Hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-valsartan Major
- Amifostine + Hydrochlorothiazide-valsartan Major
- Amiloride + Hydrochlorothiazide-valsartan Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Hydrochlorothiazide-valsartan?
MediHelp rates the interaction as moderate. Cyclophosphamide and Hydrochlorothiazide-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may increase the myelosuppressive effect of cyclophosphamide, leading to more pronounced leukopenia. The effect has been reported in limited data. Thiazide-induced fluid and electrolyte shifts may also be relevant.
How serious is the interaction between Cyclophosphamide and Hydrochlorothiazide-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during cyclophosphamide therapy. Adjust the cyclophosphamide dose according to neutrophil counts, and consider an alternative antihypertensive if cytopenias are severe.
What other medicines interact with Hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-valsartan page.
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