Drug interactions
Cyclophosphamide + Palifermin
Severity: Moderate
Cyclophosphamide and Palifermin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic chemotherapy can stimulate proliferation of epithelial cells and make them more vulnerable to the chemotherapy. Labeling reports worse and longer oral mucositis when it is given within 24 hours of chemotherapy.
What this interaction means in plain words
Cyclophosphamide and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin stimulates epithelial cell proliferation, sensitizing rapidly dividing mucosal cells to cytotoxic injury.
What to do
Do not give palifermin within 24 hours before, during infusion of, or within 24 hours after cyclophosphamide. Follow the labeled timing schedule.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Palifermin
Frequently asked questions
Can I take Cyclophosphamide with Palifermin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Palifermin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close to cytotoxic chemotherapy can stimulate proliferation of epithelial cells and make them more vulnerable to the chemotherapy. Labeling reports worse and longer oral mucositis when it is given within 24 hours of chemotherapy.
How serious is the interaction between Cyclophosphamide and Palifermin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during infusion of, or within 24 hours after cyclophosphamide. Follow the labeled timing schedule.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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