Drug interactions
Cyclophosphamide + Sorafenib
Severity: Minor
Cyclophosphamide and Sorafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib is reported to inhibit CYP2B6 in vitro, which could reduce activation of cyclophosphamide. Clinical relevance is unclear, and both drugs can cause hematologic toxicity.
What this interaction means in plain words
Cyclophosphamide and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Possible inhibition of CYP2B6-mediated cyclophosphamide activation by sorafenib, supported mainly by in vitro data.
What to do
No dose adjustment is routinely required; monitor blood counts and treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Sorafenib
Frequently asked questions
Can I take Cyclophosphamide with Sorafenib?
MediHelp rates the interaction as minor. Cyclophosphamide and Sorafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sorafenib is reported to inhibit CYP2B6 in vitro, which could reduce activation of cyclophosphamide. Clinical relevance is unclear, and both drugs can cause hematologic toxicity.
How serious is the interaction between Cyclophosphamide and Sorafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely required; monitor blood counts and treatment response.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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