Drug interactions
Cyclophosphamide + Vinorelbine
Severity: Moderate
Cyclophosphamide and Vinorelbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, so combined use can deepen neutropenia and raise infection risk. The legacy CYP3A4 rationale is not established.
What this interaction means in plain words
Cyclophosphamide and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Vinorelbine belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow suppression.
What to do
Monitor complete blood counts before each cycle and reduce doses for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Vinorelbine
Frequently asked questions
Can I take Cyclophosphamide with Vinorelbine?
MediHelp rates the interaction as moderate. Cyclophosphamide and Vinorelbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, so combined use can deepen neutropenia and raise infection risk. The legacy CYP3A4 rationale is not established.
How serious is the interaction between Cyclophosphamide and Vinorelbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts before each cycle and reduce doses for significant neutropenia.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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