Drug interactions
Cyclosporin + Deflazacort
Severity: Major
Cyclosporin and Deflazacort: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase exposure to deflazacort's active metabolite, increasing corticosteroid adverse effects and infection risk. Both drugs are immunosuppressive.
What this interaction means in plain words
Cyclosporin and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Deflazacort belongs to Miscellaneous.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, and additive immunosuppression occurs.
What to do
Consider reducing the deflazacort dose and monitor for corticosteroid toxicity, infections and cyclosporine levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Cyclosporin with Deflazacort?
MediHelp rates the interaction as major. Cyclosporin and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine may increase exposure to deflazacort's active metabolite, increasing corticosteroid adverse effects and infection risk. Both drugs are immunosuppressive.
How serious is the interaction between Cyclosporin and Deflazacort?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the deflazacort dose and monitor for corticosteroid toxicity, infections and cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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