Drug interactions
Cyclosporin + Diazepam
Severity: Minor
Cyclosporin and Diazepam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may modestly increase diazepam concentrations, potentially increasing sedation and psychomotor impairment.
What this interaction means in plain words
Cyclosporin and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Diazepam belongs to Musculoskeletal.
Why it happens
Cyclosporine inhibits CYP3A4, which contributes to diazepam metabolism.
What to do
Monitor for excess sedation and lower the diazepam dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Diazepam
Frequently asked questions
Can I take Cyclosporin with Diazepam?
MediHelp rates the interaction as minor. Cyclosporin and Diazepam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may modestly increase diazepam concentrations, potentially increasing sedation and psychomotor impairment.
How serious is the interaction between Cyclosporin and Diazepam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and lower the diazepam dose if needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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