Drug interactions
Cyclosporin + Drospirenone
Severity: Moderate
Cyclosporin and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has potassium-sparing anti-mineralocorticoid activity, and cyclosporin also tends to cause hyperkalemia. Together they may raise serum potassium, particularly in patients with renal impairment.
What this interaction means in plain words
Cyclosporin and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Drospirenone belongs to Endocrine.
Why it happens
Additive potassium-retaining effects from drospirenone's anti-mineralocorticoid action and cyclosporin-induced reduced renal potassium excretion.
What to do
Check serum potassium and renal function during the first treatment cycle and periodically afterwards; consider a non-drospirenone contraceptive if potassium rises.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Drospirenone
Frequently asked questions
Can I take Cyclosporin with Drospirenone?
MediHelp rates the interaction as moderate. Cyclosporin and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has potassium-sparing anti-mineralocorticoid activity, and cyclosporin also tends to cause hyperkalemia. Together they may raise serum potassium, particularly in patients with renal impairment.
How serious is the interaction between Cyclosporin and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function during the first treatment cycle and periodically afterwards; consider a non-drospirenone contraceptive if potassium rises.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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