Drug interactions
Cyclosporin + Erlotinib
Severity: Moderate
Cyclosporin and Erlotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may increase erlotinib exposure, potentially increasing rash, diarrhea and other adverse effects. Both CYP3A4 and efflux transporters are involved in erlotinib clearance.
What this interaction means in plain words
Cyclosporin and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Erlotinib belongs to Oncology.
Why it happens
Cyclosporin inhibits CYP3A4 and P-glycoprotein, reducing erlotinib metabolism and efflux.
What to do
Monitor for erlotinib toxicity and reduce the dose stepwise if severe reactions occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Erlotinib
- Amobarbital + Erlotinib Major
- Apalutamide + Erlotinib Major
- Carbamazepine + Erlotinib Major
- Cobicistat + Erlotinib Major
- Darunavir + Erlotinib Major
- Dexlansoprazole + Erlotinib Major
Frequently asked questions
Can I take Cyclosporin with Erlotinib?
MediHelp rates the interaction as moderate. Cyclosporin and Erlotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may increase erlotinib exposure, potentially increasing rash, diarrhea and other adverse effects. Both CYP3A4 and efflux transporters are involved in erlotinib clearance.
How serious is the interaction between Cyclosporin and Erlotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for erlotinib toxicity and reduce the dose stepwise if severe reactions occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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