Drug interactions
Cyclosporin + Fludrocortisone
Severity: Moderate
Cyclosporin and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may raise corticosteroid concentrations, while corticosteroids can change cyclosporin levels in either direction. Both can cause hypertension, fluid retention and potassium disturbances.
What this interaction means in plain words
Cyclosporin and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Fludrocortisone belongs to Endocrine.
Why it happens
Shared CYP3A4 and P-glycoprotein pathways, plus additive effects on blood pressure and electrolytes.
What to do
Monitor blood pressure, electrolytes and cyclosporin trough levels when starting, stopping or adjusting fludrocortisone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Cyclosporin with Fludrocortisone?
MediHelp rates the interaction as moderate. Cyclosporin and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin may raise corticosteroid concentrations, while corticosteroids can change cyclosporin levels in either direction. Both can cause hypertension, fluid retention and potassium disturbances.
How serious is the interaction between Cyclosporin and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, electrolytes and cyclosporin trough levels when starting, stopping or adjusting fludrocortisone.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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