Drug interactions
Cyclosporin + Flurbiprofen
Severity: Major
Cyclosporin and Flurbiprofen: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurbiprofen can reduce renal perfusion by inhibiting prostaglandins and may amplify cyclosporine nephrotoxicity. The risk is greater with dehydration or pre-existing renal disease.
What this interaction means in plain words
Cyclosporin and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive renal vasoconstriction from prostaglandin inhibition and calcineurin inhibition.
What to do
Prefer a non-NSAID analgesic; if used, monitor serum creatinine and blood pressure and stop the NSAID if renal function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Cyclosporin with Flurbiprofen?
MediHelp rates the interaction as major. Cyclosporin and Flurbiprofen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Flurbiprofen can reduce renal perfusion by inhibiting prostaglandins and may amplify cyclosporine nephrotoxicity. The risk is greater with dehydration or pre-existing renal disease.
How serious is the interaction between Cyclosporin and Flurbiprofen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-NSAID analgesic; if used, monitor serum creatinine and blood pressure and stop the NSAID if renal function declines.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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