Drug interactions
Cyclosporin + Ibrutinib
Severity: Major
Cyclosporin and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and can raise ibrutinib exposure. Higher ibrutinib levels increase the risk of bleeding, arrhythmia, cytopenias and infection.
What this interaction means in plain words
Cyclosporin and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Ibrutinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces ibrutinib clearance and increases systemic exposure.
What to do
Reduce the ibrutinib dose per labeling for moderate or strong CYP3A inhibitors and monitor for bleeding, arrhythmias and cytopenias. Restore the usual dose after cyclosporine is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Cyclosporin with Ibrutinib?
MediHelp rates the interaction as major. Cyclosporin and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and P-glycoprotein and can raise ibrutinib exposure. Higher ibrutinib levels increase the risk of bleeding, arrhythmia, cytopenias and infection.
How serious is the interaction between Cyclosporin and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the ibrutinib dose per labeling for moderate or strong CYP3A inhibitors and monitor for bleeding, arrhythmias and cytopenias. Restore the usual dose after cyclosporine is stopped.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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