Drug interactions
Cyclosporin + Imipramine
Severity: Moderate
Cyclosporin and Imipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase imipramine concentrations, raising the risk of anticholinergic effects, sedation, orthostasis and cardiac conduction effects. Reports of this interaction are limited.
What this interaction means in plain words
Cyclosporin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Imipramine belongs to Central Nervous System.
Why it happens
Cyclosporine inhibits CYP3A4 and possibly other pathways involved in imipramine metabolism.
What to do
Monitor for tricyclic toxicity and consider an ECG in at-risk patients. Reduce the imipramine dose if adverse effects emerge or levels are high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Cyclosporin with Imipramine?
MediHelp rates the interaction as moderate. Cyclosporin and Imipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase imipramine concentrations, raising the risk of anticholinergic effects, sedation, orthostasis and cardiac conduction effects. Reports of this interaction are limited.
How serious is the interaction between Cyclosporin and Imipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity and consider an ECG in at-risk patients. Reduce the imipramine dose if adverse effects emerge or levels are high.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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