Drug interactions
Cyclosporin + Lefamulin
Severity: Moderate
Cyclosporin and Lefamulin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine increases lefamulin exposure, which may raise the risk of adverse effects including QT prolongation. Lefamulin tablets are affected more than the IV form.
What this interaction means in plain words
Cyclosporin and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Lefamulin belongs to Anti Bacterial.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing lefamulin clearance and efflux.
What to do
Monitor for lefamulin adverse effects and consider ECG monitoring. Consider an alternative antibiotic in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lefamulin
- Lefamulin + Methadone Contraindicated
- Lefamulin + Pimavanserin Contraindicated
- Lefamulin + Pimozide Contraindicated
- Lefamulin + Quinidine Contraindicated
- Alfuzosin + Lefamulin Major
- Amiodarone + Lefamulin Major
Frequently asked questions
Can I take Cyclosporin with Lefamulin?
MediHelp rates the interaction as moderate. Cyclosporin and Lefamulin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine increases lefamulin exposure, which may raise the risk of adverse effects including QT prolongation. Lefamulin tablets are affected more than the IV form.
How serious is the interaction between Cyclosporin and Lefamulin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lefamulin adverse effects and consider ECG monitoring. Consider an alternative antibiotic in patients with other QT risk factors.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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