Drug interactions
Cyclosporin + Mavacamten
Severity: Major
Cyclosporin and Mavacamten: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin may raise mavacamten exposure, increasing the risk of an excessive drop in left ventricular ejection fraction and heart failure.
What this interaction means in plain words
Cyclosporin and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Mavacamten belongs to Cardiovascular.
Why it happens
Cyclosporin inhibits CYP3A4 and may inhibit other pathways, reducing the metabolism of mavacamten, which also relies on CYP2C19.
What to do
Monitor echocardiographic ejection fraction and clinical status closely, and adjust the mavacamten dose per labeling when starting or stopping cyclosporin. Interrupt mavacamten if ejection fraction falls or heart failure symptoms develop.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Cyclosporin with Mavacamten?
MediHelp rates the interaction as major. Cyclosporin and Mavacamten can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporin may raise mavacamten exposure, increasing the risk of an excessive drop in left ventricular ejection fraction and heart failure.
How serious is the interaction between Cyclosporin and Mavacamten?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor echocardiographic ejection fraction and clinical status closely, and adjust the mavacamten dose per labeling when starting or stopping cyclosporin. Interrupt mavacamten if ejection fraction falls or heart failure symptoms develop.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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