Drug interactions
Cyclosporin + Metreleptin
Severity: Moderate
Cyclosporin and Metreleptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin may change cyclosporine metabolism via effects on CYP450 enzymes, leading to unpredictable blood levels. Subtherapeutic or toxic levels may result.
What this interaction means in plain words
Cyclosporin and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Metreleptin belongs to Endocrine.
Why it happens
Leptin may alter CYP450 expression, and metabolic improvement may change cyclosporine clearance.
What to do
Monitor cyclosporine trough concentrations and renal function when starting, adjusting or stopping metreleptin, and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metreleptin
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Metreleptin?
MediHelp rates the interaction as moderate. Cyclosporin and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin may change cyclosporine metabolism via effects on CYP450 enzymes, leading to unpredictable blood levels. Subtherapeutic or toxic levels may result.
How serious is the interaction between Cyclosporin and Metreleptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function when starting, adjusting or stopping metreleptin, and adjust the dose.
What other medicines interact with Metreleptin?
MediHelp also lists interactions of Metreleptin with, for example, Insulin aspart, Insulin glargine-lixisenatide, Insulin glargine. The full list is on the Metreleptin page.
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