Drug interactions
Insulin glargine + Metreleptin
Severity: Major
Insulin glargine and Metreleptin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin improves insulin sensitivity, and combining it with insulin can cause hypoglycemia, sometimes severe. Insulin doses often need to be lowered substantially.
What this interaction means in plain words
Insulin glargine and Metreleptin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin glargine belongs to Endocrine; Metreleptin belongs to Endocrine.
Why it happens
Metreleptin improves insulin sensitivity and lowers glucose, adding to the effect of exogenous insulin.
What to do
Monitor glucose closely when starting metreleptin and reduce the insulin dose proactively, with further adjustment as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Insulin glargine
Other interactions of Metreleptin
- Insulin aspart + Metreleptin Major
- Insulin glargine-lixisenatide + Metreleptin Major
- Insulin lispro + Metreleptin Major
- Chlorpropamide + Metreleptin Moderate
- Cyclosporin + Metreleptin Moderate
- Gliclazide + Metreleptin Moderate
Frequently asked questions
Can I take Insulin glargine with Metreleptin?
MediHelp rates the interaction as major. Insulin glargine and Metreleptin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Metreleptin improves insulin sensitivity, and combining it with insulin can cause hypoglycemia, sometimes severe. Insulin doses often need to be lowered substantially.
How serious is the interaction between Insulin glargine and Metreleptin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely when starting metreleptin and reduce the insulin dose proactively, with further adjustment as needed.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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