Drug interactions
Cyclosporin + Mifamurtide
Severity: Contraindicated
Cyclosporin and Mifamurtide: contraindicated interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifamurtide works by activating monocytes and macrophages, whereas cyclosporin suppresses immune cell function. Concurrent use may blunt the therapeutic effect of mifamurtide.
What this interaction means in plain words
Cyclosporin and Mifamurtide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Mifamurtide belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism: calcineurin inhibition impairs macrophage and phagocytic activation that mifamurtide relies on.
What to do
Do not use calcineurin inhibitors with mifamurtide; consider an alternative immunosuppressive strategy.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Mifamurtide
- Doxorubicin + Mifamurtide Moderate
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Mifamurtide?
MediHelp rates the interaction as contraindicated. Cyclosporin and Mifamurtide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mifamurtide works by activating monocytes and macrophages, whereas cyclosporin suppresses immune cell function. Concurrent use may blunt the therapeutic effect of mifamurtide.
How serious is the interaction between Cyclosporin and Mifamurtide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use calcineurin inhibitors with mifamurtide; consider an alternative immunosuppressive strategy.
What other medicines interact with Mifamurtide?
MediHelp also lists interactions of Mifamurtide with, for example, Doxorubicin. The full list is on the Mifamurtide page.
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