Drug interactions
Cyclosporin + Mitoxantrone
Severity: Moderate
Cyclosporin and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase mitoxantrone exposure, which could intensify myelosuppression and cardiotoxicity. Both drugs are also immunosuppressive, which adds to infection risk.
What this interaction means in plain words
Cyclosporin and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Mitoxantrone belongs to Central Nervous System.
Why it happens
Cyclosporine inhibits P-glycoprotein and BCRP efflux transporters, potentially reducing mitoxantrone elimination, with additive immunosuppression.
What to do
Monitor complete blood counts closely and assess cardiac function (e.g. LVEF) per mitoxantrone protocols.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Mitoxantrone
Frequently asked questions
Can I take Cyclosporin with Mitoxantrone?
MediHelp rates the interaction as moderate. Cyclosporin and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may increase mitoxantrone exposure, which could intensify myelosuppression and cardiotoxicity. Both drugs are also immunosuppressive, which adds to infection risk.
How serious is the interaction between Cyclosporin and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely and assess cardiac function (e.g. LVEF) per mitoxantrone protocols.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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