Drug interactions
Cyclosporin + Naproxen
Severity: Major
Cyclosporin and Naproxen: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these drugs increase the risk of acute kidney injury, hyperkalemia, fluid retention and hypertension. Renal function may deteriorate rapidly, especially with volume depletion.
What this interaction means in plain words
Cyclosporin and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Naproxen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins combined with cyclosporine-induced afferent arteriolar vasoconstriction produces additive nephrotoxicity.
What to do
Avoid the combination where possible, or use the lowest NSAID dose for the shortest time. Monitor serum creatinine, potassium and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Cyclosporin with Naproxen?
MediHelp rates the interaction as major. Cyclosporin and Naproxen can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together these drugs increase the risk of acute kidney injury, hyperkalemia, fluid retention and hypertension. Renal function may deteriorate rapidly, especially with volume depletion.
How serious is the interaction between Cyclosporin and Naproxen?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest NSAID dose for the shortest time. Monitor serum creatinine, potassium and blood pressure.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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