Drug interactions
Cyclosporin + Nifedipine
Severity: Moderate
Cyclosporin and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine may modestly increase cyclosporine levels and both drugs are associated with gingival hyperplasia, which can be more severe in combination. Cyclosporine may also increase nifedipine exposure, causing hypotension or edema.
What this interaction means in plain words
Cyclosporin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Nifedipine belongs to Cardiovascular.
Why it happens
Possible CYP3A4 competition affecting cyclosporine and nifedipine clearance, plus additive gingival overgrowth effects.
What to do
Monitor cyclosporine trough levels, blood pressure and gingival health. Adjust the doses if levels or tolerability change, or consider a different antihypertensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Nifedipine
Frequently asked questions
Can I take Cyclosporin with Nifedipine?
MediHelp rates the interaction as moderate. Cyclosporin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nifedipine may modestly increase cyclosporine levels and both drugs are associated with gingival hyperplasia, which can be more severe in combination. Cyclosporine may also increase nifedipine exposure, causing hypotension or edema.
How serious is the interaction between Cyclosporin and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels, blood pressure and gingival health. Adjust the doses if levels or tolerability change, or consider a different antihypertensive.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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