Drug interactions
Cyclosporin + Oxcarbazepine
Severity: Moderate
Cyclosporin and Oxcarbazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may reduce cyclosporine concentrations, raising the risk of under-immunosuppression and rejection. The inductive effect is weaker than that of carbamazepine but is clinically relevant.
What this interaction means in plain words
Cyclosporin and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine and its active metabolite weakly induce CYP3A4, accelerating cyclosporine metabolism.
What to do
Monitor cyclosporine trough levels after starting or stopping oxcarbazepine and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Cyclosporin with Oxcarbazepine?
MediHelp rates the interaction as moderate. Cyclosporin and Oxcarbazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine may reduce cyclosporine concentrations, raising the risk of under-immunosuppression and rejection. The inductive effect is weaker than that of carbamazepine but is clinically relevant.
How serious is the interaction between Cyclosporin and Oxcarbazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels after starting or stopping oxcarbazepine and adjust the dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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