Drug interactions
Cyclosporin + Pantoprazole
Severity: Minor
Cyclosporin and Pantoprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged proton pump inhibitor therapy can cause hypomagnesemia, and cyclosporine also promotes renal magnesium loss. Combined use can therefore increase the risk of low magnesium, which may cause arrhythmias or seizures.
What this interaction means in plain words
Cyclosporin and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Additive effects on magnesium: reduced intestinal absorption with PPIs and increased renal wasting with cyclosporine.
What to do
Check serum magnesium periodically during long-term combined use and supplement if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Frequently asked questions
Can I take Cyclosporin with Pantoprazole?
MediHelp rates the interaction as minor. Cyclosporin and Pantoprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prolonged proton pump inhibitor therapy can cause hypomagnesemia, and cyclosporine also promotes renal magnesium loss. Combined use can therefore increase the risk of low magnesium, which may cause arrhythmias or seizures.
How serious is the interaction between Cyclosporin and Pantoprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium periodically during long-term combined use and supplement if low.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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