Drug interactions
Cyclosporin + Pasireotide
Severity: Moderate
Cyclosporin and Pasireotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatostatin analogues can lower the absorption of oral cyclosporine, which may reduce its blood levels. This could lead to loss of immunosuppressive effect and rejection or disease flare.
What this interaction means in plain words
Cyclosporin and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Pasireotide belongs to Endocrine.
Why it happens
Reduced gastrointestinal absorption of cyclosporine; the exact mechanism is not fully established.
What to do
Monitor cyclosporine trough concentrations when starting, changing or stopping pasireotide, and adjust the cyclosporine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Cyclosporin with Pasireotide?
MediHelp rates the interaction as moderate. Cyclosporin and Pasireotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatostatin analogues can lower the absorption of oral cyclosporine, which may reduce its blood levels. This could lead to loss of immunosuppressive effect and rejection or disease flare.
How serious is the interaction between Cyclosporin and Pasireotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations when starting, changing or stopping pasireotide, and adjust the cyclosporine dose accordingly.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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