Drug interactions
Cyclosporin + Pazopanib
Severity: Moderate
Cyclosporin and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise pazopanib concentrations, increasing the risk of hepatotoxicity, hypertension and QT prolongation. Pazopanib may also affect cyclosporine exposure.
What this interaction means in plain words
Cyclosporin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Pazopanib belongs to Oncology.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein/BCRP, reducing pazopanib clearance.
What to do
Monitor liver function tests, blood pressure and ECG, and reduce the pazopanib dose if toxicity occurs. Monitor cyclosporine levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Cyclosporin with Pazopanib?
MediHelp rates the interaction as moderate. Cyclosporin and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise pazopanib concentrations, increasing the risk of hepatotoxicity, hypertension and QT prolongation. Pazopanib may also affect cyclosporine exposure.
How serious is the interaction between Cyclosporin and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests, blood pressure and ECG, and reduce the pazopanib dose if toxicity occurs. Monitor cyclosporine levels.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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