Drug interactions
Cyclosporin + Ponesimod
Severity: Major
Cyclosporin and Ponesimod: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponesimod lowers circulating lymphocytes, and combining it with cyclosporine adds to immunosuppression and infection risk. The effect may persist for weeks after stopping either drug.
What this interaction means in plain words
Cyclosporin and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Ponesimod belongs to Central Nervous System.
Why it happens
Additive immunosuppression via S1P receptor modulation and calcineurin inhibition.
What to do
Avoid combination where possible; if used, monitor for infection and lymphocyte counts. Consider the long-lasting immune effects when switching therapies.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Ponesimod
- Fingolimod + Ponesimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Amiodarone + Ponesimod Major
- Amisulpride + Ponesimod Major
- Anagrelide + Ponesimod Major
- Anti-thymocyte + Ponesimod Major
Frequently asked questions
Can I take Cyclosporin with Ponesimod?
MediHelp rates the interaction as major. Cyclosporin and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ponesimod lowers circulating lymphocytes, and combining it with cyclosporine adds to immunosuppression and infection risk. The effect may persist for weeks after stopping either drug.
How serious is the interaction between Cyclosporin and Ponesimod?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; if used, monitor for infection and lymphocyte counts. Consider the long-lasting immune effects when switching therapies.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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