Drug reference
ponesimod
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Central Nervous System (MS Drugs)
Mechanism of action
Sphingosine 1-phosphate (S1P) receptor 1 modulator that binds with high affinity to S1P receptor 1
Blocks capacity of lymphocytes to regress from lymph nodes, reducing number of lymphocytes in peripheral blood
Common side effects
- Dizziness
- Somnolence
- Dyspnea
- Cough
- Hypertension
- Pain in extremity
- Elevated hepatic transaminases
- Urinary tract infection
- Upper respiratory infection
Contraindications
- Presence of Mobitz type II second-degree, third-degree AV block, or sick sinus syndrome, unless patient has functioning pacemaker
- In the past 6 months, experienced myocardial infarction, unstable angina, stroke, TIA, decompensated heart failure (HF) requiring hospitalization, or Class III/IV HF
Related conditions
Frequently asked questions
What drug class is ponesimod?
ponesimod belongs to: Central Nervous System.
How does ponesimod work?
Sphingosine 1-phosphate (S1P) receptor 1 modulator that binds with high affinity to S1P receptor 1 Blocks capacity of lymphocytes to regress from lymph nodes, reducing number of lymphocytes in peripheral blood
What are the common side effects of ponesimod?
Dizziness, Somnolence, Dyspnea, Cough, Hypertension, Pain in extremity, Elevated hepatic transaminases, Urinary tract infection, Upper respiratory infection
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