Drug interactions
Cyclosporin + Prednisolone
Severity: Moderate
Cyclosporin and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can increase prednisolone exposure, and corticosteroids may in turn change cyclosporine levels. Combined use is common in transplantation, but both effects increase immunosuppression and adverse effects.
What this interaction means in plain words
Cyclosporin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Prednisolone belongs to Endocrine.
Why it happens
Mutual interaction through CYP3A4 and P-glycoprotein, with additive immunosuppression.
What to do
Monitor cyclosporine trough levels and corticosteroid adverse effects, including infection and hyperglycemia. Adjust doses as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Cyclosporin with Prednisolone?
MediHelp rates the interaction as moderate. Cyclosporin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can increase prednisolone exposure, and corticosteroids may in turn change cyclosporine levels. Combined use is common in transplantation, but both effects increase immunosuppression and adverse effects.
How serious is the interaction between Cyclosporin and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and corticosteroid adverse effects, including infection and hyperglycemia. Adjust doses as clinically indicated.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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