Drug interactions
Cyclosporin + Streptomycin
Severity: Major
Cyclosporin and Streptomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are nephrotoxic, and streptomycin is also ototoxic, so combined use increases the risk of acute kidney injury and hearing or vestibular damage. Renal impairment further raises aminoglycoside levels.
What this interaction means in plain words
Cyclosporin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity from cyclosporine renal vasoconstriction and aminoglycoside tubular toxicity, with added aminoglycoside ototoxicity.
What to do
Avoid if alternatives exist; otherwise monitor serum creatinine, streptomycin levels and cyclosporine levels, and assess hearing and vestibular function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Streptomycin
Frequently asked questions
Can I take Cyclosporin with Streptomycin?
MediHelp rates the interaction as major. Cyclosporin and Streptomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and streptomycin is also ototoxic, so combined use increases the risk of acute kidney injury and hearing or vestibular damage. Renal impairment further raises aminoglycoside levels.
How serious is the interaction between Cyclosporin and Streptomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if alternatives exist; otherwise monitor serum creatinine, streptomycin levels and cyclosporine levels, and assess hearing and vestibular function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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