Drug interactions
Cyclosporin + Sunitinib
Severity: Moderate
Cyclosporin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise sunitinib and its active metabolite exposure, increasing toxicities such as myelosuppression, hypertension, hepatotoxicity and QT prolongation. Sunitinib is also immunosuppressive, adding to infection risk.
What this interaction means in plain words
Cyclosporin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Sunitinib belongs to Oncology.
Why it happens
Cyclosporine inhibits CYP3A4-mediated sunitinib metabolism.
What to do
Monitor for sunitinib toxicity and consider reducing the sunitinib dose if adverse effects develop. Monitor cyclosporine levels as well.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Cyclosporin with Sunitinib?
MediHelp rates the interaction as moderate. Cyclosporin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise sunitinib and its active metabolite exposure, increasing toxicities such as myelosuppression, hypertension, hepatotoxicity and QT prolongation. Sunitinib is also immunosuppressive, adding to infection risk.
How serious is the interaction between Cyclosporin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sunitinib toxicity and consider reducing the sunitinib dose if adverse effects develop. Monitor cyclosporine levels as well.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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