Drug interactions
Cyclosporin + Tadalafil
Severity: Minor
Cyclosporin and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase tadalafil exposure, which can increase hypotension, headache, flushing and dyspepsia. The effect is modest, and tadalafil does not meaningfully change cyclosporine levels.
What this interaction means in plain words
Cyclosporin and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Tadalafil belongs to Genitourinary.
Why it happens
Cyclosporine inhibits CYP3A4 metabolism of tadalafil.
What to do
Start tadalafil at the lowest dose, particularly for pulmonary hypertension, and monitor blood pressure and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Frequently asked questions
Can I take Cyclosporin with Tadalafil?
MediHelp rates the interaction as minor. Cyclosporin and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine may increase tadalafil exposure, which can increase hypotension, headache, flushing and dyspepsia. The effect is modest, and tadalafil does not meaningfully change cyclosporine levels.
How serious is the interaction between Cyclosporin and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start tadalafil at the lowest dose, particularly for pulmonary hypertension, and monitor blood pressure and tolerability.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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