Drug interactions
Cyclosporin + Tisagenlecleucel
Severity: Major
Cyclosporin and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressants such as cyclosporine may impair the expansion and persistence of CAR T cells and so reduce their efficacy. They also add to infection risk in patients who are already immunocompromised.
What this interaction means in plain words
Cyclosporin and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Tisagenlecleucel belongs to Oncology.
Why it happens
Calcineurin inhibition suppresses T-cell activation and proliferation, counteracting CAR T-cell function.
What to do
Avoid cyclosporine before and around infusion unless clearly necessary, and follow the product labeling on washout periods. Monitor for infection and treatment response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Cyclosporin with Tisagenlecleucel?
MediHelp rates the interaction as major. Cyclosporin and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Immunosuppressants such as cyclosporine may impair the expansion and persistence of CAR T cells and so reduce their efficacy. They also add to infection risk in patients who are already immunocompromised.
How serious is the interaction between Cyclosporin and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid cyclosporine before and around infusion unless clearly necessary, and follow the product labeling on washout periods. Monitor for infection and treatment response.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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