Drug interactions
Cyclosporin + Tocilizumab
Severity: Moderate
Cyclosporin and Tocilizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the immune system, so combined use raises the risk of serious infection. Tocilizumab also reverses IL-6 mediated suppression of CYP3A4, which may lower cyclosporine concentrations.
What this interaction means in plain words
Cyclosporin and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Tocilizumab belongs to Musculoskeletal.
Why it happens
Additive immunosuppression, plus IL-6 blockade restoring CYP3A4 activity and increasing cyclosporine clearance.
What to do
Monitor for infection and check cyclosporine trough levels when starting or stopping tocilizumab, adjusting the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tocilizumab
- Bcg vaccine live + Tocilizumab Contraindicated
- Measles mumps and rubella vaccine live + Tocilizumab Contraindicated
- Measles mumps rubella and varicella vaccine live + Tocilizumab Contraindicated
- Measles vaccine + Tocilizumab Contraindicated
- Rubella vaccine + Tocilizumab Contraindicated
- Smallpox vaccine live + Tocilizumab Contraindicated
Frequently asked questions
Can I take Cyclosporin with Tocilizumab?
MediHelp rates the interaction as moderate. Cyclosporin and Tocilizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the immune system, so combined use raises the risk of serious infection. Tocilizumab also reverses IL-6 mediated suppression of CYP3A4, which may lower cyclosporine concentrations.
How serious is the interaction between Cyclosporin and Tocilizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for infection and check cyclosporine trough levels when starting or stopping tocilizumab, adjusting the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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