Drug interactions
Cyclosporin + Tolterodine
Severity: Moderate
Cyclosporin and Tolterodine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin inhibits CYP3A4 and may raise tolterodine exposure, particularly in people who are poor CYP2D6 metabolisers. This can increase anticholinergic effects such as dry mouth, constipation, blurred vision and urinary retention, and may add to QT concerns.
What this interaction means in plain words
Cyclosporin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Tolterodine belongs to Genitourinary.
Why it happens
Cyclosporin inhibits CYP3A4, which is a secondary metabolic pathway for tolterodine.
What to do
No routine dose change is needed; monitor for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Tolterodine
Frequently asked questions
Can I take Cyclosporin with Tolterodine?
MediHelp rates the interaction as moderate. Cyclosporin and Tolterodine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin inhibits CYP3A4 and may raise tolterodine exposure, particularly in people who are poor CYP2D6 metabolisers. This can increase anticholinergic effects such as dry mouth, constipation, blurred vision and urinary retention, and may add to QT concerns.
How serious is the interaction between Cyclosporin and Tolterodine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for anticholinergic adverse effects and reduce the tolterodine dose if they occur.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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