Drug interactions
Cyclosporin + Vincristine
Severity: Major
Cyclosporin and Vincristine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin inhibits both P-glycoprotein and CYP3A4 and can raise vincristine exposure. This increases the risk of neurotoxicity such as peripheral neuropathy, constipation or ileus, and seizures.
What this interaction means in plain words
Cyclosporin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Vincristine belongs to Oncology.
Why it happens
Cyclosporin inhibits P-glycoprotein efflux and CYP3A4 metabolism of vincristine.
What to do
Avoid the combination if possible. If it is needed, monitor closely for neuropathy, constipation and ileus, and consider reducing the vincristine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Frequently asked questions
Can I take Cyclosporin with Vincristine?
MediHelp rates the interaction as major. Cyclosporin and Vincristine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporin inhibits both P-glycoprotein and CYP3A4 and can raise vincristine exposure. This increases the risk of neurotoxicity such as peripheral neuropathy, constipation or ileus, and seizures.
How serious is the interaction between Cyclosporin and Vincristine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is needed, monitor closely for neuropathy, constipation and ileus, and consider reducing the vincristine dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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