Drug interactions
Cyclosporine + Dutasteride-tamsulosin
Severity: Moderate
Cyclosporine and Dutasteride-tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may raise tamsulosin and dutasteride exposure. This could increase dizziness and orthostatic hypotension from tamsulosin.
What this interaction means in plain words
Cyclosporine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reducing metabolism and efflux of tamsulosin and dutasteride.
What to do
Monitor blood pressure and orthostatic symptoms when cyclosporine is started or its dose changes. Consider lowering the tamsulosin dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Cyclosporine with Dutasteride-tamsulosin?
MediHelp rates the interaction as moderate. Cyclosporine and Dutasteride-tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may raise tamsulosin and dutasteride exposure. This could increase dizziness and orthostatic hypotension from tamsulosin.
How serious is the interaction between Cyclosporine and Dutasteride-tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when cyclosporine is started or its dose changes. Consider lowering the tamsulosin dose if adverse effects occur.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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