Drug interactions
Cyclosporine + Fosinopril-hydrochlorothiazide
Severity: Moderate
Cyclosporine and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine can cause hyperkalemia, hypertension and nephrotoxicity, while ACE inhibitors add to hyperkalemia and reduce glomerular filtration pressure. Hydrochlorothiazide may raise uric acid and cause electrolyte disturbances including hyponatremia, and renal function may deteriorate.
What this interaction means in plain words
Cyclosporine and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on renal hemodynamics, potassium handling and electrolytes through combined cyclosporine, ACE inhibitor and thiazide actions.
What to do
Monitor serum sodium, potassium and creatinine regularly, along with cyclosporine levels and blood pressure; adjust therapy if electrolytes or renal function worsen.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Cyclosporine with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cyclosporine and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine can cause hyperkalemia, hypertension and nephrotoxicity, while ACE inhibitors add to hyperkalemia and reduce glomerular filtration pressure. Hydrochlorothiazide may raise uric acid and cause electrolyte disturbances including hyponatremia, and renal function may deteriorate.
How serious is the interaction between Cyclosporine and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium and creatinine regularly, along with cyclosporine levels and blood pressure; adjust therapy if electrolytes or renal function worsen.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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