Drug interactions
Cyclosporine + Mifepristone
Severity: Major
Cyclosporine and Mifepristone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and may raise cyclosporine levels, which carries a risk of nephrotoxicity and other toxicity. Cyclosporine has a narrow therapeutic index.
What this interaction means in plain words
Cyclosporine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Mifepristone inhibits CYP3A4-mediated cyclosporine metabolism.
What to do
Avoid the combination, especially with repeated mifepristone dosing. If a single abortion dose is unavoidable, monitor cyclosporine trough levels and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Cyclosporine with Mifepristone?
MediHelp rates the interaction as major. Cyclosporine and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone inhibits CYP3A4 and may raise cyclosporine levels, which carries a risk of nephrotoxicity and other toxicity. Cyclosporine has a narrow therapeutic index.
How serious is the interaction between Cyclosporine and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, especially with repeated mifepristone dosing. If a single abortion dose is unavoidable, monitor cyclosporine trough levels and renal function.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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