Drug interactions
Cyclosporine + Neomycin
Severity: Moderate
Cyclosporine and Neomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine is nephrotoxic, and oral neomycin can be absorbed to a small degree, particularly with inflamed bowel or renal impairment. Together there is a potential for additive kidney injury and ototoxicity, and neomycin may also modestly reduce cyclosporine absorption.
What this interaction means in plain words
Cyclosporine and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity from systemically absorbed neomycin and cyclosporine.
What to do
Monitor serum creatinine and cyclosporine trough levels when neomycin is used, especially for prolonged courses or with impaired renal function. Limit neomycin duration and avoid it in significant renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Neomycin
- Amikacin + Neomycin Major
- Amphotericin b deoxycholate + Neomycin Major
- Capreomycin + Neomycin Major
- Cidofovir + Neomycin Major
- Colistin + Neomycin Major
- Ethacrynic acid + Neomycin Major
Frequently asked questions
Can I take Cyclosporine with Neomycin?
MediHelp rates the interaction as moderate. Cyclosporine and Neomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine is nephrotoxic, and oral neomycin can be absorbed to a small degree, particularly with inflamed bowel or renal impairment. Together there is a potential for additive kidney injury and ototoxicity, and neomycin may also modestly reduce cyclosporine absorption.
How serious is the interaction between Cyclosporine and Neomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and cyclosporine trough levels when neomycin is used, especially for prolonged courses or with impaired renal function. Limit neomycin duration and avoid it in significant renal impairment.
What other medicines interact with Neomycin?
MediHelp also lists interactions of Neomycin with, for example, Amikacin, Amphotericin b deoxycholate, Capreomycin. The full list is on the Neomycin page.
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