Drug interactions
Cyclosporine + Pyrazinamide
Severity: Moderate
Cyclosporine and Pyrazinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
A transplant case report described a fall in cyclosporine concentrations after pyrazinamide was started. Subtherapeutic cyclosporine could risk graft rejection, though evidence is very limited.
What this interaction means in plain words
Cyclosporine and Pyrazinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is unknown.
What to do
Monitor cyclosporine trough levels when pyrazinamide is started or stopped and adjust the dose accordingly. Watch for signs of rejection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyrazinamide
- Pexidartinib + Pyrazinamide Major
- Pretomanid + Pyrazinamide Major
- Isoniazid + Pyrazinamide Moderate
- Mipomersen + Pyrazinamide Moderate
- Probenecid + Pyrazinamide Moderate
- Pyrazinamide + Rifampin Moderate
Frequently asked questions
Can I take Cyclosporine with Pyrazinamide?
MediHelp rates the interaction as moderate. Cyclosporine and Pyrazinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. A transplant case report described a fall in cyclosporine concentrations after pyrazinamide was started. Subtherapeutic cyclosporine could risk graft rejection, though evidence is very limited.
How serious is the interaction between Cyclosporine and Pyrazinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels when pyrazinamide is started or stopped and adjust the dose accordingly. Watch for signs of rejection.
What other medicines interact with Pyrazinamide?
MediHelp also lists interactions of Pyrazinamide with, for example, Pexidartinib, Pretomanid, Isoniazid. The full list is on the Pyrazinamide page.
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