Drug interactions
Mipomersen + Pyrazinamide
Severity: Moderate
Mipomersen and Pyrazinamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can raise liver enzymes and cause hepatotoxicity. Together they may increase the risk of liver injury.
What this interaction means in plain words
Mipomersen and Pyrazinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hepatotoxicity.
What to do
Monitor liver function tests at baseline and regularly during combined use. Stop one agent if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pyrazinamide
- Pexidartinib + Pyrazinamide Major
- Pretomanid + Pyrazinamide Major
- Cyclosporine + Pyrazinamide Moderate
- Isoniazid + Pyrazinamide Moderate
- Probenecid + Pyrazinamide Moderate
- Pyrazinamide + Rifampin Moderate
Frequently asked questions
Can I take Mipomersen with Pyrazinamide?
MediHelp rates the interaction as moderate. Mipomersen and Pyrazinamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can raise liver enzymes and cause hepatotoxicity. Together they may increase the risk of liver injury.
How serious is the interaction between Mipomersen and Pyrazinamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests at baseline and regularly during combined use. Stop one agent if significant elevations occur.
What other medicines interact with Pyrazinamide?
MediHelp also lists interactions of Pyrazinamide with, for example, Pexidartinib, Pretomanid, Cyclosporine. The full list is on the Pyrazinamide page.
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