Drug interactions
Cyclosporine + Rosuvastatin
Severity: Major
Cyclosporine and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine markedly increases rosuvastatin exposure. The risk of myopathy and rhabdomyolysis is substantially higher.
What this interaction means in plain words
Cyclosporine and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cyclosporine inhibits OATP1B1 and BCRP, reducing rosuvastatin uptake and clearance.
What to do
Limit rosuvastatin to 5 mg daily with cyclosporine per labeling, or choose an alternative statin. Monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Cyclosporine with Rosuvastatin?
MediHelp rates the interaction as major. Cyclosporine and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine markedly increases rosuvastatin exposure. The risk of myopathy and rhabdomyolysis is substantially higher.
How serious is the interaction between Cyclosporine and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rosuvastatin to 5 mg daily with cyclosporine per labeling, or choose an alternative statin. Monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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