Drug interactions
Cyclosporine + Saxagliptin-metformin
Severity: Minor
Cyclosporine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine is a moderate CYP3A4/P-gp inhibitor and may modestly increase saxagliptin exposure. The effect on saxagliptin is not usually clinically important and needs no dose change.
What this interaction means in plain words
Cyclosporine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces saxagliptin metabolism and efflux.
What to do
No routine dose change is needed. Monitor glucose and renal function, since cyclosporine is nephrotoxic and renal impairment affects metformin safety.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Frequently asked questions
Can I take Cyclosporine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Cyclosporine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclosporine is a moderate CYP3A4/P-gp inhibitor and may modestly increase saxagliptin exposure. The effect on saxagliptin is not usually clinically important and needs no dose change.
How serious is the interaction between Cyclosporine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor glucose and renal function, since cyclosporine is nephrotoxic and renal impairment affects metformin safety.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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