Drug interactions
Cyproheptadine + Desvenlafaxine
Severity: Moderate
Cyproheptadine and Desvenlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine blocks serotonin 5-HT2A receptors and may reduce the therapeutic serotonergic effect of SNRIs. This could lead to diminished antidepressant or anxiolytic response.
What this interaction means in plain words
Cyproheptadine and Desvenlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Desvenlafaxine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism of serotonin receptors by cyproheptadine.
What to do
Monitor for worsening mood or anxiety symptoms when cyproheptadine is started, and reassess the need for it if response declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Desvenlafaxine
- Desvenlafaxine + Isocarboxazid Contraindicated
- Desvenlafaxine + Methylene blue Contraindicated
- Desvenlafaxine + Phenelzine Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
- Desvenlafaxine + Safinamide Contraindicated
- Desvenlafaxine + Selegiline Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Desvenlafaxine?
MediHelp rates the interaction as moderate. Cyproheptadine and Desvenlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine blocks serotonin 5-HT2A receptors and may reduce the therapeutic serotonergic effect of SNRIs. This could lead to diminished antidepressant or anxiolytic response.
How serious is the interaction between Cyproheptadine and Desvenlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for worsening mood or anxiety symptoms when cyproheptadine is started, and reassess the need for it if response declines.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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