Drug interactions
Cyproheptadine + Diazepam
Severity: Moderate
Cyproheptadine and Diazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Together these agents can cause additive sedation, slowed reaction time and impaired memory and coordination. Risk is higher in older adults and with alcohol.
What this interaction means in plain words
Cyproheptadine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Diazepam belongs to Musculoskeletal.
Why it happens
Additive CNS depression via H1 blockade and GABA-A potentiation.
What to do
Monitor for oversedation and falls, and use the lowest effective doses. Advise avoiding driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Diazepam
Frequently asked questions
Can I take Cyproheptadine with Diazepam?
MediHelp rates the interaction as moderate. Cyproheptadine and Diazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Together these agents can cause additive sedation, slowed reaction time and impaired memory and coordination. Risk is higher in older adults and with alcohol.
How serious is the interaction between Cyproheptadine and Diazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and use the lowest effective doses. Advise avoiding driving and alcohol.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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