Drug interactions
Cyproheptadine + Dosulepin
Severity: Moderate
Cyproheptadine and Dosulepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dosulepin is a sedating tricyclic with anticholinergic effects, and cyproheptadine adds to both. This can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion, and cyproheptadine may blunt antidepressant response.
What this interaction means in plain words
Cyproheptadine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Dosulepin belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects, with 5-HT2 antagonism by cyproheptadine.
What to do
Monitor for sedation, anticholinergic toxicity and loss of antidepressant efficacy, using lower doses in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Dosulepin
- Dosulepin + Isocarboxazid Contraindicated
- Dosulepin + Phenelzine Contraindicated
- Dosulepin + Thioridazine Contraindicated
- Dosulepin + Tranylcypromine Contraindicated
- Amitriptyline + Dosulepin Major
- Buprenorphine + Dosulepin Major
Frequently asked questions
Can I take Cyproheptadine with Dosulepin?
MediHelp rates the interaction as moderate. Cyproheptadine and Dosulepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dosulepin is a sedating tricyclic with anticholinergic effects, and cyproheptadine adds to both. This can cause marked drowsiness, dry mouth, constipation, urinary retention and confusion, and cyproheptadine may blunt antidepressant response.
How serious is the interaction between Cyproheptadine and Dosulepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic toxicity and loss of antidepressant efficacy, using lower doses in older patients.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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