Drug interactions
Cyproheptadine + Frovatriptan
Severity: Minor
Cyproheptadine and Frovatriptan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a 5-HT2 antagonist and could theoretically reduce serotonin-mediated effects of triptans. Frovatriptan acts at 5-HT1B/1D receptors, so a real loss of migraine relief is uncertain.
What this interaction means in plain words
Cyproheptadine and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Frovatriptan belongs to Central Nervous System.
Why it happens
Possible pharmacodynamic opposition at serotonin receptors, although receptor subtypes differ.
What to do
No routine change is needed. If migraine relief is inadequate, review whether cyproheptadine is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Frovatriptan
- Almotriptan + Frovatriptan Contraindicated
- Dihydroergotamine intranasal + Frovatriptan Contraindicated
- Dihydroergotamine + Frovatriptan Contraindicated
- Eletriptan + Frovatriptan Contraindicated
- Ergoloid mesylates + Frovatriptan Contraindicated
- Ergotamine + Frovatriptan Contraindicated
Frequently asked questions
Can I take Cyproheptadine with Frovatriptan?
MediHelp rates the interaction as minor. Cyproheptadine and Frovatriptan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyproheptadine is a 5-HT2 antagonist and could theoretically reduce serotonin-mediated effects of triptans. Frovatriptan acts at 5-HT1B/1D receptors, so a real loss of migraine relief is uncertain.
How serious is the interaction between Cyproheptadine and Frovatriptan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. If migraine relief is inadequate, review whether cyproheptadine is needed.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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