Drug interactions
Cyproheptadine + Ganaxolone
Severity: Moderate
Cyproheptadine and Ganaxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ganaxolone is a neuroactive steroid anticonvulsant that causes somnolence, and cyproheptadine adds sedation. The combination may worsen drowsiness and impaired alertness.
What this interaction means in plain words
Cyproheptadine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Ganaxolone belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A positive modulation and H1 antagonism.
What to do
Monitor for excessive sedation and reduce the dose of cyproheptadine if needed. Counsel against driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyproheptadine and Ganaxolone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Ganaxolone
Frequently asked questions
Can I take Cyproheptadine with Ganaxolone?
MediHelp rates the interaction as moderate. Cyproheptadine and Ganaxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ganaxolone is a neuroactive steroid anticonvulsant that causes somnolence, and cyproheptadine adds sedation. The combination may worsen drowsiness and impaired alertness.
How serious is the interaction between Cyproheptadine and Ganaxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the dose of cyproheptadine if needed. Counsel against driving until the combined effect is known.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
