Drug interactions
Cyproheptadine + Hyaluronidase
Severity: Minor
Cyproheptadine and Hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Labeling for hyaluronidase notes that antihistamines in large systemic doses can make tissues partly resistant to its spreading action. A larger hyaluronidase dose may be needed to obtain the usual dispersion effect.
What this interaction means in plain words
Cyproheptadine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyproheptadine belongs to Respiratory; Hyaluronidase belongs to Miscellaneous.
Why it happens
Antihistamines may reduce tissue responsiveness to hyaluronidase; the exact mechanism is not well established.
What to do
Assess the dispersion response after hyaluronidase administration in patients on high-dose antihistamines. Give additional hyaluronidase if the effect is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Cyproheptadine with Hyaluronidase?
MediHelp rates the interaction as minor. Cyproheptadine and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Labeling for hyaluronidase notes that antihistamines in large systemic doses can make tissues partly resistant to its spreading action. A larger hyaluronidase dose may be needed to obtain the usual dispersion effect.
How serious is the interaction between Cyproheptadine and Hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the dispersion response after hyaluronidase administration in patients on high-dose antihistamines. Give additional hyaluronidase if the effect is inadequate.
What other medicines interact with Cyproheptadine?
MediHelp also lists interactions of Cyproheptadine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Cyproheptadine page.
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